Personally, I like cross-compiling. From the perspective of the features a modern IDE (and even text editor) provide. Using a mouse to quickly navigate between files, copy/paste text etc. Using Alt+Tab to flick between source code, API/Reference documents, and graphic editors etc. I am also quite an erratic developer, I'll fly between developing different parts of a program on a whim, so trying to develop with line numbers and the like make that harder
Then you also have some extra options with regards to compilers. I used cc65 for my last C64 project. Sure, it doesn't produce the most streamlined code, but as I was rusty with any C64 assembler, it seemed the quickest way to attempt my port.